| 摘要 |
Disclosed are novel N-(3-heteroarylaryl)-4-arylarylcarboxamides and analogs thereof, represented by the Formula I: wherein C cyclic group, D1-D4, Q1, Q2, R5 are defined herein. Compounds having Formula (I) are hedgehog pathway inhibitors. Therefore, compounds of the invention may be used to treat clinical conditions that are responsive to the inhibition of hedgehog activity, such as cancer.; |
| 主权项 |
1. A compound having the Formula I: or a pharmaceutically acceptable salt or prodrug thereof, wherein: C cyclic group is an optionally substituted N-containing heteroaryl; D1 is N or CR6; D2 is N or CR7; D3 is N or CR8; D4 is N or CR9; Q1 and Q2 independently are optionally substituted aryl, heteroaryl, a carbocyclic group or heterocyclic group; R6-R9 independently are hydrogen, halo, optionally substituted amino, alkoxy, C1-10 alkyl, C3-8 cycloalkyl, haloalkyl, aryl, a carbocyclic group, a heterocyclic group, heteroaryl, alkenyl, alkynyl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, heteroarylalkenyl, heteroarylalkynyl, carbocycloalkyl, heterocycloalkyl, hydroxyalkyl, hydroxyalkoxy, aminoalkyl, aminoalkoxy, carboxyalkyl, carboxyalkoxy, nitro, cyano, acylamino, aminocarbonyl, hydroxy, thiol, acyloxy, azido, carboxy, hydroxyacylamino, alkylsulfonyl, aminosulfonyl, dialkylaminosulfonyl, alkylsulfinyl, or alkylthiol; and R5 is hydrogen or C1-10 alkyl, or R5 is taken together with N atom to which it is attached, and other groups, and an atom of Q1 to form a heterocyclic group. |
