发明名称 |
METHODS TO TREAT NEURODEGENERATIVE DISEASES |
摘要 |
The present invention is based on the discovery that motor neurons derived from patients with a neuro-degenerative disease have decreased delayed rectifier potassium current and increased persistent sodium current compared to motor neurons derived from control healthy individuals. The present invention is also based on the discovery that the class of compounds known as “potassium channel openers” can be used to treat neurodegenerative diseases, including ALS, Parkinson's disease, Alzheimer's disease, epilepsy, and pain. |
申请公布号 |
US2015190363(A1) |
申请公布日期 |
2015.07.09 |
申请号 |
US201314420245 |
申请日期 |
2013.08.06 |
申请人 |
Children's Medical Center Corporation ;President and Fellows of Harvard College |
发明人 |
Woolf Clifford J.;Wainger Brian;Kiskinis Evangelos;Eggan Kevin |
分类号 |
A61K31/325;G01N33/483;G01N33/50;A61K31/428 |
主分类号 |
A61K31/325 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Boston MA US |