| 摘要 |
<p>A process for preparing an injectable biocompatible implant was developed in which microspheres formed by a seeded polymerization technique are mechanically separated and cleaned at elevated temperature. The process results in a monodisperse microsphere preparation with an average microsphere diameter of between about 20 μm to 50 μm and coefficient of variation of less than 10%. The monodispersity of the microspheres enables the separation and cleaning steps of this novel process. The process reduces the small particles responsible for blood clotting and granuloma formation in patients. The microsphere preparation is combined with a suspension agent, such as porcine collagen or hyaluronic acid, to form the injectable biocompatible implant.</p> |
