| 发明名称 |
METHODS AND REAGENTS FOR PREVENTION AND/OR TREATMENT OF TRANSPLANT REJECTION |
| 摘要 |
The present invention relates to methods for determining the probability of transplant rejection based on the determination in the subject recipient of the transplant of the levels of antibodies specific for hyaluronic acid. The invention relates as well to methods for attenuating transplant rejection and compositions to prevent transplant rejection based on the depletion of anti-hyaluronic acid antibodies from the subject. |
| 申请公布号 |
US2015192576(A1) |
申请公布日期 |
2015.07.09 |
| 申请号 |
US201314421555 |
申请日期 |
2013.08.12 |
| 申请人 |
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE (IDIBELL) |
发明人 |
Mañez Mendiluce Rafael |
| 分类号 |
G01N33/53;A61K35/16;A61K35/18 |
主分类号 |
G01N33/53 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for determining the probability of transplant rejection in a subject who has been subjected to transplantation that comprises determining in a sample from said subject the levels of antibodies specific for at least one hyaluronic acid oligosaccharide, wherein if the levels of antibodies specific for said at least one hyaluronic acid oligosaccharide are modified with respect to a reference value, then there is a high probability of transplant rejection in said subject. |
| 地址 |
L'Hospitalet de Llobregat ES |
