| 主权项 |
1. A compound of structural formula I:or a pharmaceutically acceptable salt thereof; whereinX is selected from the group consisting of:
(1) oxygen, and (2) NH;T is selected from the group consisting of: CH, N and N-oxide;U is selected from the group consisting of: CH, N and N-oxide;V is selected from the group consisting of: CH, N and N-oxide;provided that one or two of T, U and V is N or N-oxide;A is selected from the group consisting of:
(1) aryl, and (2) heteroaryl,wherein A is unsubstituted or substituted with one to five substituents selected from Ra;B is selected from the group consisting of:
(1) aryl, (2) aryl-O—, (3) C3-6cycloalkyl-, (4) C3-6cycloalkyl-C1-10alkyl-, (5) C3-6cycloalkyl-C1-10alkyl-O—, (6) C2-5 cycloheteroalkyl-, (7) heteroaryl, (8) heteroaryl-O—, (9) aryl-C1-10 alkyl-, and (10) heteroaryl-C1-10 alkyl-,wherein B is unsubstituted or substituted with one to five substituents selected from Rb;R1 is selected from the group consisting of:
(1) halogen, (2) —ORe, (3) —CN, (4) —C1-6 alkyl, and (5) —C3-6cycloalkyl,wherein each —C1-6alkyl and —C3-6cycloalkyl is unsubstituted or substituted with one to three substituents selected from Ri;R2 is selected from the group consisting of:
(1) hydrogen, (2) —C1-6 alkyl, and (3) —C3-6cycloalkyl,wherein each —C1-6alkyl and —C3-6cycloalkyl is unsubstituted or substituted with one to three substituents selected from Rj;R3 is selected from the group consisting of:
(1) hydrogen, (2) halogen, (3) —ORe, (4) —C1-6 alkyl, (5) —C2-6alkenyl, (6) —C2-6alkynyl, and (7) —C3-6cycloalkyl,wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, and C3-6cycloalkyl is unsubstituted or substituted with one to three substituents selected from RL;R4 is selected from the group consisting of:
(1) hydrogen, (2) halogen, (3) —ORe, (4) —C1-6 alkyl, (5) —C2-6alkenyl, (6) —C2-6alkynyl, and (7) —C3-6cycloalkyl,wherein each —C1-6alkyl, —C2-6alkenyl, —C2-6alkynyl, and —C3-6cycloalkyl is unsubstituted or substituted with one to three substituents selected from RL;R5 is selected from the group consisting of:
(1) hydrogen, (2) —C1-3 alkyl, and (3) halogen;R6 is selected from the group consisting of:
(1) hydrogen, (2) —C1-3 alkyl, and (3) halogen, orR5 and R6 can together form oxo;Ra is selected from the group consisting of:
(1) —C1-6alkyl, (2) halogen, (3) —ORe, (4) —NRcS(O)mRe, (5) —S(O)mRe, (6) —S(O)mNRcRd, (7) —NRcRd, (8) —C(O)Re, (9) —OC(O)Re, (10) —CO2Re, (11) —CN, (12) —C(O)NRcRd, (13) —NRcC(O)Re, (14) —NRcC(O)ORe, (15) —NRcC(O)NRcRd, (16) —CF3, (17) —OCF3, (18) —OCHF2, (19) —C3-6cycloalkyl, and (20) —C2-5cycloheteroalkyl;Rb is independently selected from the group consisting of:
(1) —C1-10alkyl, (2) —C2-10 alkenyl, (3) halogen, (4) —OH, (5) —OC1-10alkyl, (6) —OC2-10 alkenyl, (7) —O(CH2)pOC1-10alkyl, (8) —O(CH2)pC3-6cycloalkyl, (9) —O(CH2)pC3-6 cycloalkyl-C1-10 alkyl-, (10) —O(CH2)pC2-10cycloheteroalkyl, (11) —O(CH2)pC2-5cycloheteroalkyl-C1-10 alkyl-, (12) —O-aryl, (13) —O-heteroaryl, (14) —O-aryl-C1-10 alkyl-, (15) —O-heteroaryl-C1-10 alkyl-, (16) —NRcS(O)mRe, (17) —S(O)mRe, (18) —S(O)mNRcRd, (19) —NRcRd, (20) —C(O)Re, (21) —OC(O)Re, (22) —CO2Re, (23) —CN, (24) —C(O)NRcRd, (25) —NRcC(O)Re, (26) —NRcC(O)ORe, (27) —NRcC(O)NRcRd, (28) —O(CH2)pO—C3-6cycloalkyl, (29) —O(CH2)pO—C2-10cycloheteroalkyl, (30) —CF3, (31) —OCF3, (32) —OCHF2, (33) —(CH2)p-C3-6cycloalkyl, (34) —(CH2)p-C2-10cycloheteroalkyl, (35) aryl, (36) heteroaryl, (37) aryl-C1-10 alkyl-, and (38) heteroaryl-C1-10 alkyl-,wherein each Rb is unsubstituted or substituted with one to five substituents selected from Rk;Rc and Rd are each independently selected from the group consisting of:
(1) hydrogen, (2) C1-10alkyl, (3) C2-10alkenyl, (4) C3-6cycloalkyl, (5) C3-6 cycloalkyl-C1-10alkyl-, (6) cycloheteroalkyl, (7) cycloheteroalkyl-C1-10alkyl-, (8) aryl, (9) heteroaryl, (10) aryl-C1-10alkyl-, and (11) heteroaryl-C1-10alkyl-, orRc and Rd together with the atom(s) to which they are attached form a cycloheteroalkyl ring of 4 to 7 members containing 0-2 additional heteroatoms independently selected from oxygen, sulfur and N—Rg,and wherein each Rc and Rd is unsubstituted or substituted with one to three substituents independently selected from Rf;each Re is independently selected from the group consisting of:
(1) hydrogen, (2) —C1-10alkyl, (3) —C2-10 alkenyl, (4) —C3-6 cycloalkyl, (5) —C3-6cycloalkyl-C1-10alkyl-, (6) —C2-5cycloheteroalkyl, (7) —C2-5cycloheteroalkyl-C1-10alkyl-, (8) aryl, (9) heteroaryl, (10) aryl-C1-10alkyl-, and (11) heteroaryl-C1-10alkyl-,wherein each Re is unsubstituted or substituted with one to three substituents selected from Rh;each Rf is selected from the group consisting of:
(1) halogen, (2) C1-10alkyl, (3) —OH, (4) —O—C1-4alkyl, (5) —S(O)m—C1-4alkyl, (6) —CN, (7) —CF3, (8) —OCHF2, and (9) —OCF3,wherein each C1-10 alkyl is unsubstituted or substituted with one to three substituents independently selected from: —OH, halogen, cyano, and —S(O)2CH3;each Rg is selected from the group consisting of:
(1) hydrogen, (2) —C(O)Re, and (3) —C1-10alkyl,wherein —C1-10alkyl is unsubstituted or substituted with one to five fluorines;each Rh is selected from the group consisting of:
(1) halogen, (2) —C1-10alkyl, (3) —OH, (4) —O—C1-4alkyl, (5) —S(O)m—C1-4alkyl, (6) —CN, (7) —CF3, (8) —OCHF2, and (9) —OCF3,wherein each C1-10 alkyl is unsubstituted or substituted with one to three substituents independently selected from: —OH, halogen, cyano, and —S(O)2CH3;Ri is independently selected from the group consisting of:
(1) —C1-6alkyl, (2) —ORe, (3) —NRcS(O)mRe, (4) halogen, (5) —S(O)mRe, (6) —S(O)mNRcRd, (7) —NRcRd, (8) —C(O)Re, (9) —OC(O)Re, (10) —CO2Re, (11) —CN, (12) —C(O)NRcRd, (13) —NRcC(O)Re, (14) —NRcC(O)ORe, (15) —NRcC(O)NRcRd, (16) —CF3, (17) —OCF3, (18) —OCHF2, (19) —C3-6cycloalkyl, and (20) —C2-5cycloheteroalkyl;Rj is independently selected from the group consisting of:
(1) —C1-6alkyl, (2) —ORe, (3) —NRcS(O)mRe, (4) halogen, (5) —S(O)mRe, (6) —S(O)mNRcRd, (7) —NRcRd, (8) —C(O)Re, (9) —OC(O)Re, (10) —CO2Re, (11) —CN, (12) —C(O)NRcRd, (13) —NRcC(O)Re, (14) —NRcC(O)ORe, (15) —NRcC(O)NRcRd, (16) —CF3, (17) —OCF3, (18) —OCHF2, (19) —C3-6cycloalkyl, and (20) —C2-5cycloheteroalkyl;each Rk is independently selected from the group consisting of:
(1) halogen, (2) —C1-10 alkyl, (3) —OH, (4) oxo, (5) halogen, (6) —O—C1-4 alkyl, (7) —SO2—C1-6 alkyl, (8) —C1-6 alkyl-SO2C1-6alkyl, (9) —CN, (10) —CF3, (11) —OCHF2, (12) —OCF3, (13) —NH2, (14) —NHSO2C1-6alkyl, (15) —NHCOC1-6alkyl, (16) ═N(OCH3), (17) —P(O)(OH)2, and (18) —P(O)(OC1-6alkyl)2,wherein each C1-10 alkyl is unsubstituted or substituted with one to three substituents independently selected from: —OH, —OC1-6alkyl, halogen, cyano, and —S(O)2C1-6alkyl;RL is selected from the group consisting of:
(1) —C1-6alkyl, (2) halogen, (3) —ORe, (4) —NRcS(O)mRe, (5) —S(O)mRe, (6) —S(O)mNRcRd, (7) —NRcRd, (8) —C(O)Re, (9) —OC(O)Re, (10) —CO2Re, (11) —CN, (12) —C(O)NRcRd, (13) —NRcC(O)Re, (14) —NRcC(O)ORe, (15) —NRcC(O)NRcRd, (16) —CF3, (17) —OCF3, (18) —OCHF2, (19) —C3-6cycloalkyl, and (20) —C2-5cycloheteroalkyl;each n is independently selected from: 0, 1, 2, 3 or 4;each m is independently selected from: 0, 1 or 2; andeach p is independently selected from: 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10. |
