| 发明名称 |
METHODS FOR REDUCING CELLULAR SENESCENCE MEDIATED BY DNA DAMAGING AGENTS |
| 摘要 |
A method for reducing cellular senescence in a subject, in particular a subject exposed to or at risk of being exposed to a DNA damaging agents, e.g., radiation, by inhibiting PAI-1 activity in the subject with a truncated PAI-1 agent, rPAI-123. |
| 申请公布号 |
US2015190484(A1) |
申请公布日期 |
2015.07.09 |
| 申请号 |
US201514661686 |
申请日期 |
2015.03.18 |
| 申请人 |
Trustees of Dartmouth College ;The Government of the United States, as represented by the Secretary, Department of Health |
发明人 |
Mulligan-Kehoe Mary Jo;Citrin Deborah Eva;Chung Eunjoo S.;Mitchell James |
| 分类号 |
A61K38/57 |
主分类号 |
A61K38/57 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for reducing cellular senescence mediated by a DNA damaging agent comprising administering to a subject in need thereof an effective amount of rPAI-123 thereby reducing cellular senescence. |
| 地址 |
Hanover NH US |
