FICUS EXTRACTS HAVING ANGIOGENESIS INHIBITING ACTIVITY AND METHODS OF ISOLATING AND USING THE SAME

摘要

The present invention is directed to methods for extracting and isolating extracts having angiogenesis inhibiting activity from a latex-containing portion of a Ficus variant, pharmaceutical and nutraceutical compositions comprising the extracts, methods of administering the extracts to treat angiogenesis-dependent diseases and to reduce or inhibit neovessel growth in a subject in need thereof and the use of the extracts in the manufacture of a composition for reducing or inhibiting neovessel growth.

主权项

1. A method for inhibiting growth of at least one tumor in a mammal in need thereof, said method comprising providing to said mammal a Ficus extract, wherein said Ficus extract is prepared by a process comprising:
a) mixing a latex-containing portion of a Ficus variant with a polar solvent to provide a liquid extract; b) washing the liquid extract with an organic solvent to provide an aqueous extract; and c) fractionating the aqueous extract to provide a Ficus extract having angiogenesis inhibiting activity.