发明名称 |
FILAGGRIN PRODUCTION PROMOTER, THERAPEUTIC AGENT FOR DISEASES ASSOCIATED WITH REDUCTION IN PRODUCTION OF FILAGGRIN, AND METHOD FOR SCREENING FOR SAID THERAPEUTIC AGENT |
摘要 |
The present invention provides a highly effective substance having a filaggrin production-promoting action. The present invention also provides a therapeutic agent useful for treating a skin disease, in particular, atopic dermatitis associated with reduced filaggrin production. As a result of intensive studies on a filaggrin production promoter, it has been found that A) an N-quinolylbenzamide derivative (Compound 1), B) ivermectin (Compound 2), or C) a phenylalaninamide derivative (Compound 3) promotes production of filaggrin in skin and satisfactorily improves a water retention ability and barrier function of the stratum corneum. The present invention relates to a filaggrin production promoter containing a certain N-quinolylbenzamide derivative or a pharmaceutically acceptable salt thereof as an active ingredient. |
申请公布号 |
US2015190416(A1) |
申请公布日期 |
2015.07.09 |
申请号 |
US201314414940 |
申请日期 |
2013.07.12 |
申请人 |
KYOTO UNIVERSITY ;ASTELLAS PHARMA INC. |
发明人 |
Kabashima Kenji;Otsuka Atsushi;Egawa Gyohei;Doi Hiromi;Maekawa Akiko;Narumiya Shuh |
分类号 |
A61K31/7048;A61K31/4439;C12Q1/68;A61K31/47 |
主分类号 |
A61K31/7048 |
代理机构 |
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代理人 |
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主权项 |
1. A therapeutic agent for a disease associated with reduced filaggrin (FLG) production, comprising a GPR142 agonist as an active ingredient. |
地址 |
Kyoto JP |