Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof

摘要

The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, a wound (the compounds assist with wound healing), acne, rheumatoid arthritis, psoriasis, rosacea, and alopecia; Kennedy's disease (spinal and bulbar muscular atrophy, or SBMA), polyglutamine-mediated motor neuron degeneration; cancers such as prostate cancer, bladder cancer, breast cancer, ovarian cancer, hepatocellular (liver) cancer, and pancreatic cancer; and other medical conditions described herein. Treatment of such medical conditions includes administering to an individual suffering from a medical condition describe herein, a therapeutically effective amount of any of the disclosed compounds, their derivatives, or pharmaceutical compositions thereof.

主权项

1. A pharmaceutical composition for treating a subject suffering from an androgen receptor associated medical condition, comprising:
a compound according to formula VIII: wherein: R1 and R2 are mono- or di-substituted groups, a methoxy group (—OCH3), a hydroxyl group (—OH), or an alkyl sulfonyl group, or —OSO2C2H5; R1 and R2 could be the same or different; R3 is selected from the group consisting ofand
R4 is selected from the group consisting of CH3, H, F and Cl; n is 1 or 2; and
further wherein said pharmaceutical composition treats said subject suffering from said androgen receptor associated medical condition.