| 摘要 |
<p>A process for the preparation of topiramate in an one pot reaction comprises the following steps: A) reacting 2,3:4,5-bis-O-{1-methylethylidene)-β-D-fructopyranose with sulfurylchloride in xylene in the presence of an organic or inorganic base to form 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfuryl chloride, B) adding a second organic solvent to the mixture obtained in step A) C) reacting the mixture obtained in step B) with ammonia to form topiramate.</p> |
