３α−ヒドロキシ−３β−メチル−５α−プレグナン−２０−オン（ガナキソロン）の製造法

摘要

Applicants have discovered a method for the stereoselective and regioselective synthesis of 3α-hydroxy, 3β-methyl-5α-pregnan-20-one (ganaxolone) comprising reacting 5α-pregnane-3,20-dione; with an organometallic methylating agent in an inert solvent to provide a compound of the formula