发明名称 |
HYPERBARIC DEVICE AND METHODS FOR PRODUCING INACTIVATED VACCINES AND FOR REFOLDING/SOLUBILIZING RECOMBINANT PROTEINS |
摘要 |
The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions. |
申请公布号 |
EP2890393(A2) |
申请公布日期 |
2015.07.08 |
申请号 |
EP20130766420 |
申请日期 |
2013.08.30 |
申请人 |
MERIAL, INC.;TOP INDUSTRIE S.A.S. |
发明人 |
CARBOULEC, NICOLAS PIERRE, YVES;MERIAN, GILDAS;LABATUT, RENÉ;GERENTES, LIONEL |
分类号 |
A61K39/008;A23L3/015;C07K1/113;C12N15/62 |
主分类号 |
A61K39/008 |
代理机构 |
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代理人 |
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