TRANSGENIC CLAWED FROG EMBRYOS AND USE THEREOF AS DETECTORS OF ENDOCRINE DISRUPTERS IN THE ENVIRONMENT

摘要

The invention relates to transgenic aquatic animals, particularly the clawed frog and the zebra fish and cells derived therefrom, characterized in comprising at least one expression cassette with a regulatory DNA sequence selected from the response elements to nuclear hormone receptors, particularly TRE, connected in a functional manner downstream of a DNA segment coding for a marker protein such as luciferase or GFP. The invention further relates to methods using the transgenic cells and animals according to the invention for the identification of endocrine disrupters in the environment.