摘要 |
The invention comprises 2-(p-chlorophenyl)-indone-1,3-dione and the following methods for the preparation thereof: (1) condensing phthalic acid anhydride and p-chlorophenyl acetic acid in the presence of molten sodium acetate and converting the p-chlorophenyl phthalide so obtained into 2-(p-chlorophenyl)-indone-1,3-dione by boiling with an alcohol solution of an alkali metal alcoholate; (2) condensing a phthalic acid dialkyl ester in which each alkyl radical contains up to 4 carbon atoms with a p-chlorophenyl acetic acid alkyl ester in the presence of an alkali metal or an alkali metal alcoholate to form 2-carbalkoxy-2-(p-chlorophenyl) - indan - 1,3 - dione which is then subjected to acid saponification and decarboxylation; (3) reacting a 2-(p-chlorophenylacetyl)-benzoic acid alkyl ester in which the alkyl radical contains up to 4 carbon atoms with a hot alcohol solution of an alkali metal alcoholate; and (4) condensing phthalide and p-chloro-benzaldehyde in the presence of a hot alcohol solution of an alkali metal alcoholate. In the examples 2-(p-chlorophenyl)-indan-1:3-dione is prepared by the methods (1) and (2) above.ALSO:A therapeutic composition suitable for oral administration as an anticoagulant comprises 2-(p-chlorophenyl)-indone-1, 3-dione and a carrier e.g., cornstarch, lactose, stearic acid, talc or magnesium stearate. |