| 摘要 |
Methods of mass spectrometry are disclosed comprising: providing supercharged analyte ions 20, preferably generated by a liquid AP-MALDI ion source; and supplying electrons or reagent ions to said analyte ions 20 so as to transfer charge from said reagent ions or electrons to said analyte ions 20, said transfer of charge causing at least some of said analyte ions to dissociate, the charge transfer step being performed at a relatively high pressure, e.g. > 0.1 mbar, and preferably at substantially at atmospheric pressure. At least some of the analyte ions may not dissociate but instead form intermediate ECnoD or ETnoD ions of an altered charge state. In this case, said intermediate ions may be isolated and excited so as to cause them to dissociate into daughter ions. |
