发明名称 Compositions and methods for treating cancer
摘要 Provided herein are methods and compositions inter alia for treating diseases, including hyperproliferative diseases, migraine headaches, and depression.
申请公布号 US9073851(B2) 申请公布日期 2015.07.07
申请号 US201213662135 申请日期 2012.10.26
申请人 Board of Regents, the University of Texas System 发明人 Ozpolat Bulent;Lopez-Berestein Gabriel;Dalby Kevin N.;Jose Jiney
分类号 A61K9/127;A01N43/42;A61K31/44;C07D209/14;C07D471/04;C07D403/12;C07D209/18;C07D471/14;C07D209/20 主分类号 A61K9/127
代理机构 Mintz Levin Cohn Ferris Glovsky and Popeo PC 代理人 Mintz Levin Cohn Ferris Glovsky and Popeo PC
主权项 1. A compound having the formula: wherein R1A is independently hydrogen, halogen, —CX1A3, —C(O)R7A, —C(O)—OR7A, —C(O)NR7AR8A, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R2A is independently hydrogen, halogen, —CX2A3, —C(O)R9A, —C(O)—OR9A, —C(O)NR9AR10A, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; wherein R1A and R2A are optionally joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; R3 is independently halogen, —CX33, —CN, —SO2Cl, —SOnR14, —SOkNR11R12, —NHNH2, —ONR11R12, —NHC═(O)NHNH2, —NHC═(O)NR11R12, —N(O)m, —NR11R12, —C(O)R13, —C(O)—OR13, —O—C(O)—R13, —C(O)NR11R12, —NR11C(O)R13, —OR14, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R7A, R8A, R9A, R10A, R11, R12, and R13 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R14 is substituted or unsubstituted C8-C16 alkyl; A1 is independently ═CR3—; k and m are independently 1 or 2; n is independently an integer from 0 to 4; z1 is independently 0; X1A X2A, and X3 are independently —Cl, —Br, —I, or —F.
地址 Austin TX US