N-acylthiourea and N-acylurea inhibitors of the Hedgehog protein signalling pathway

摘要

The present invention relates to the use of acylthiourea or acylurea derivatives for the treatment of pathologies involving a tissue dysfunction associated with a deregulation of the Hedgehog protein signalling pathway, and also to novel acylthiourea or acylurea derivatives as such, to their use as a medicinal product, and to pharmaceutical compositions containing them.

主权项

1. A method for manufacturing a drug, said method comprising mixing at least one pharmaceutically acceptable excipient and at least one compound with the following formula (I): wherein: R1, R2 and R3, which are identical or different and independent of each other, represent a hydrogen or a halogen atom, a hydroxyl radical, an alkyl, perfluoroalkyl, alkoxy, alkylthio or nitrile group, or a substituted alkoxy group; X represents a sulfur or oxygen atom; Y represents a a —NH—(C═O)—R6, or —(C═O)—NH—R6 group, wherein R6 represents a non-substituted aryl group; an aryl group comprising one or more substituents selected from a halogen atom and an alkyl, alkoxy or mono- or dialkylamino radical; a mono- or polycyclic heteroaryl group; a linear or branched alkyl radical; or a saturated or unsaturated mono- or polycyclic hydrocarbon group; R4 and R5, which are identical or different and independent of each other, represent a hydrogen or a halogen atom, or an alkoxy, alkylthio, alkyl, perfluoroalkyl, nitrile or nitro group.