| 发明名称 | Class II HMG-COA reductase inhibitors and methods of use | ||
| 摘要 | Disclosed are compositions and methods for treating bacterial infections. | ||
| 申请公布号 | US9073832(B2) | 申请公布日期 | 2015.07.07 |
| 申请号 | US201313836743 | 申请日期 | 2013.03.15 |
| 申请人 | Purdue Research Foundation | 发明人 | Stauffacher Cynthia;Lipton Mark Alfred;Saleem Mohamed Naguieb;Schmidt Tim Jonathan;Steussy, Jr. Calvin Nicklaus;Rodwell Victor W |
| 分类号 | A61K31/60;A01N37/36;C07C311/00;C07C311/29;A01N41/06 | 主分类号 | A61K31/60 |
| 代理机构 | Valauskas Corder LLC | 代理人 | Valauskas Corder LLC |
| 主权项 | 1. An inhibitor of Class II 3-hydroxy-3-methylglutaryl-coenzyme A reductase having one of the following structures: wherein: R1=is a hydroxyl; R2=is H; D is CR4, wherein R4 is (CH2)4CH(CH3)2, (CH2)3CH(CH3)2, (CH2)2C(CH3)3 cyclohexylethyl, or (CH2)mRc, wherein m=6-14 and RC=H; R5=H; A, B, E, X, Y, and Z are each CH; or a pharmaceutically acceptable salts thereof. | ||
| 地址 | West Lafayette IN US | ||