Pharmaceutical compositions comprising napthamides

摘要

Disclosed herein are naphthamide and quinoline carboxamide compounds containing two bicyclic moieties, pharmaceutical compositions comprising those compounds and methods of using the compositions in the treatment of cancers mediated by cyclic-AMP (cAMP) response element binding protein (CREB). The disclosed compositions have utility in the treatment of lung, prostate and breast cancers in a human subject.

主权项

1. A compound with the structure: wherein n is an integer selected from 0 and 1, wherein R1 is halo, wherein R2 is OH or halo, and wherein X1 and X2 are independently CH or N.