Methods and products for treating proliferative diseases

摘要

Methods and products for treating proliferative diseases, and wounds, using as a pharmacon an autophagy inhibitor, a glycolytic inhibitor, and/or an agent able to alter cellular production of reactive oxygen, or combination thereof, optionally in combination with one or more chemotherapeutic agents. In some embodiments, the invention combines a 4-aminoquinoline, exemplified by chloroquine, with a glycolytic inhibitor, exemplified by 2-deoxy-D-glucose and anti-VEGF antibodies. The systems and methods of the invention may be used to treat drug-resistant or multi-drug resistant cancers.

主权项

1. A method for treating cancer, comprising:
administering to a subject a therapeutically acceptable amount of an autophagy inhibitor and a VEGF receptor antagonist in an effective amount to treat the cancer, wherein the VEGF receptor antagonist is a small molecule inhibitor of a VEGFR tyrosine kinase and the autophagy inhibitor is chloroquine, and wherein the autophagy inhibitor and the VEGF receptor antagonist are administered sequentially.