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1. A compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof: wherein R1 and R2 are the same or different and each represent a hydrogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group or a C1-6 alkoxy group (the C1-6 alkyl group, the C1-6 alkoxy group and the C3-8 cycloalkyl group may be substituted with 1 to 3 substituents which are the same or different and are selected from “a halogen atom, a hydroxy group, a C3-8 cycloalkyl group, a C1-6 alkoxy group, a C3-8 cycloalkoxy group, an amino group, a C1-6 alkylamino group, a di(C1-6 alkyl)amino group, —N(R11)COR12, —N(R11)SO2R12, a cyano group, a carboxy group, a carbamoyl group, —CON(R13)(R14), —SO2N(R13)(R14), a C1-6 alkylthio group, a C1-6 alkylsulfonyl group, an aryloxy group, an aryl group, and a heterocyclic group”), R11, R12, R13and R14 are the same or different and each represent a hydrogen atom or a C1-6 alkyl group, R13 and R14, together with the nitrogen atom to which they are attached, may form a saturated or unsaturated 5- or 6-membered ring which may further contain one or more nitrogen atoms, oxygen atoms or sulfur atoms, R3 represents a hydrogen atom or a C1-6 alkyl group (the C1-6 alkyl group may be substituted with 1 to 3 substituents which are the same or different and are selected from “a halogen atom, a hydroxy group, a C1-6 alkoxy group, a C3-8 cycloalkoxy group, an amino group, a C1-6 alkylamino group, and a di(C1-6 alkyl)amino group”), R4 represents a hydrogen atom, a hydroxy group, a C1-6 alkoxy group, a C3-8 cycloalkoxy group, an amino group, a C1-6 alkylamino group, a di(C1-6 alkyl)amino group, a C1-6 alkyl group, a C3-8 cycloalkyl group (the C1-6 alkyl group and the C3-8 cycloalkyl group may be substituted with 1 to 3 substituents which are the same or different and are selected from
“a halogen atom, a hydroxy group, a C3-8 cycloalkyl group, a C1-6 alkoxy group, a C3-8 cycloalkoxy group, an amino group, a C1-6 alkylamino group, a di(C1-6 alkyl)amino group, —N(R41)COR42, —N(R41)SO2R42, a cyano group, a carboxy group, —CON(R43)(R44), —SO2N(R43)(R44), a C1-6 alkylthio group, a C1-6 alkylsulfonyl group, an aryl group, an aryloxy group, and a heterocyclic group (the aryl group, the aryloxy group, and the heterocyclic group may be substituted with 1 to 3 substituents which are the same or different and are selected from “a halogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, a benzyl group, a C1-6 haloalkyl group, a C1-6 hydroxyalkyl group, a C2-8 alkoxyalkyl group, a hydroxy group, a C1-6 alkoxy group, a C3-8 cycloalkoxy group, an amino group, a C1-6 alkylamino group, a di(C1-6 alkyl)amino group, —N(R45)COR46, —N(R45)SO2R46, a cyano group, a carboxy group, —CON(R47)(R48), —SO2N(R47)(R48), a C1-6 alkylthio group, and a C1-6 alkylsulfonyl group”) ”),an aryl group, or a heterocyclic group(the aryl group and the heterocyclic group may be substituted with 1 to 3 substituents which are the same or different and are selected from “a halogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C1-6 haloalkyl group, a C1-6 hydroxyalkyl group, a C2-8 alkoxyalkyl group, a hydroxy group, a C1-6 alkoxy group, a C3-8 cycloalkoxy group, an amino group, a C1-6 alkylamino group, a di(C1-6 alkyl)amino group, —N(R45)COR46, —N(R45)SO2R46, a cyano group, a carboxy group, —CON(R47)(R48), —SO2N(R47)(R48), a C1-6 alkylthio group, and a C1-6 alkylsulfonyl group”), R41, R42, R43, R44, R45, R46, R47 and R48 are the same or different and each represent a hydrogen atom or a C1-6 alkyl group, R43 and R44, together with the nitrogen atom to which they are attached, may form a saturated or unsaturated 5- or 6-membered ring which may further contain one or more nitrogen atoms, oxygen atoms or sulfur atoms, R47 and R48, together with the nitrogen atom to which they are attached, may form a saturated or unsaturated 5- or 6-membered ring which may further contain one or more nitrogen atoms, oxygen atoms or sulfur atoms, R3 and R4, together with the nitrogen atom to which they are attached, may form a saturated or unsaturated 5- or 6-membered ring which may further contain one or more nitrogen atoms, oxygen atoms or sulfur atoms, A1 represents a divalent aryl group which may be substituted with 1 to 4 substituents which are the same or different and are selected from the following group of substituents, Ra): the group of substituents, Ra, consists of a halogen atom, a hydroxy group, an amino group (the amino group may be substituted with a C2-6 alkanoyl group or one or two C1-6 alkyl groups), a carboxy group, a carbamoyl group, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C2-6 alkenyl group, and a C1-6 alkoxy group (the C1-6 alkyl group, the C3-8 cycloalkyl group, the C2-6 alkenyl group, and the C1-6 alkoxy group may be substituted with 1 to 4 substituents which are the same or different and are selected from “a halogen atom, a hydroxy group, an amino group, a carboxy group, a C1-6 alkylaminocarbonyl group, and a C1-6 alkoxycarbonyl group”), L represents —C≡C—, —C≡C—C≡C—, —CH═CH—, —CH═CH—C≡C—, or —C≡C—CH═CH—, R5 represents a hydrogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, or an aryl group, m denotes 1, 2 or 3, A2 represents a divalent aryl group which may be substituted with 1 to 4 substituents which are the same or different and are selected from the following group of substituents, Rb): the group of substituents, Rb, consists of a halogen atom, an optionally protected hydroxy group, a mercapto group, a cyano group, a nitro group, an optionally protected amino group, an optionally protected formyl group, an optionally protected carboxy group, a carbamoyl group, a sulfo group, a ureido group, a guanidido group, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C1-6 haloalkyl group, a C1-6 hydroxyalkyl group, a C1-6 alkoxy group, a C1-6 alkylamino group, a di(C1-6 alkyl)amino group, a C1-6 alkoxycarbonyl group, a C2-6 alkanoyl group, and an aryl group, W represents R6—X1—, R6—X2—Y1—X1—, R6—X4—Y1—X2—Y3—X3—, Q-X1—Y2—X3—, or Q-X1—Y1—X2—Y3—X3—, Y2 represents —O—, —NR7—, —CO—, —NR7CO—, —CONR7—, —S(O)n—, —OCO—, —COO—, —NR7SO2—, —SO2—NR7—, —OCOO—, —OCONR7—, —NR7CONR8—, or a bond, Y1 and Y3 are the same or different and each represent —O—, —NR7—, —CO—, —NR7CO—, —CONR7—, —S(O)n—, —OCO—, —COO—, —NR7SO2—, —SO2NR7—, —OCOO—, —OCONR7—, or —NR7CONR8—, n denotes 0, 1 or 2, X1 and X3 are the same or different and each represent a C1-10 alkylene group, a C2-10 alkenylene group, a C2-10 alkynylene group, a C3-8 cycloalkylene group, —C1-6 alkylene-C3-8 cycloalkylene-C1-6 alkylene- (the C1-10 alkylene group, the C2-10 alkenylene group, the C2-10 alkynylene group, the C3-8 cycloalkylene group, and the —C1-6 alkylene-C3-8 cycloalkylene-C1-6 alkylene- may be substituted with 1 to 4 substituents which are the same or different and are selected from a group of substituents, Rc, to be shown below), or a bond, X2 and X4 are the same or different and each represent a C1-10 alkylene group, a C2-10 alkenylene group, a C2-10 alkynylene group, or —C1-6 alkylene-C3-8 cycloalkylene-C1-6 alkylene-(the C1-10 alkylene group, the C2-10 alkenylene group, the C2-10 alkynylene group, and the -C1-6 alkylene-C3-8 cycloalkylene-C1-6 alkylene- may be substituted with 1 to 4 substituents which are the same or different and are selected from the group of substituents, Rc, to be shown below), Q represents a C3-8 cycloalkyl group, an aryl group, or a heterocyclic group (the C3-8 cycloalkyl group, the aryl group and the heterocyclic group may be substituted with 1 to 4 substituents which are the same or different and are selected from the group of substituents, Rc, to be shown below, and the heterocyclic group may have the different carbon atoms on the ring bridged with a C1-6 alkylene group or —C1-6 alkylene-O—C1-6 alkylene-), R6 represents a hydrogen atom, a halogen atom, an optionally protected hydroxy group, a mercapto group, a cyano group, a nitro group, an optionally protected amino group, an optionally protected formyl group, an optionally protected carboxy group, a carbamoyl group, a sulfo group, an optionally protected phosphate group, a ureido group, a guanidido group, R7—O—NR8—CO—, R8—ON═CR9—, R8—ON═CR9—NH—, R7—O—NR8—CH═N—, (R7)(R8)N—N═CH—, R8—O—NR8—, N≡C—NR8— or a C1-6 alkoxy group (the C1-6 alkoxy group may be substituted with 1 to 3 hydroxy groups), R7 and R8 are the same or different and each represent a hydrogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, an aryl group, or a heterocyclic group (the C1-6 alkyl group, the C3-8 cycloalkyl group, the aryl group and the heterocyclic group may be substituted with 1 to 4 substituents which are the same or different and are selected from the group of substituents, Rc, to be shown below), R9 represents a hydrogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, an amino group, or a C1-6 alkylamino group, and the group of substituents, Rc, consists of a halogen atom, a hydroxy group, a cyano group, a nitro group, an amino group (the amino group may be substituted with a C2-6 alkanoyl group or one or two C1-6 alkyl groups), a carboxy group, a carbamoyl group, a ureido group, a guanidido group, a C1-6 alkyl group (the C1-6 alkyl group may be substituted with a heterocyclic group), a C1-6 hydroxyalkyl group, a C1-6 haloalkyl group, a C3-8 cycloalkyl group, a C1-6 alkoxy group (the C1-6 alkoxy group may be substituted with 1 to 3 substituents which are the same or different and are selected from a hydroxy group, a halogen atom, a C3-8 cycloalkyl group, a C1-6 alkoxy group, an aryl group and a heterocyclic group), a C3-8 cycloalkoxy group, a C1-6 alkoxycarbonyl group, a C1-6 alkoxycarbonylamino group, a C2-6 alkanoyl group, a C1-6 alkylsulfonyl group, a C1-6 alkylthio group, an aryl group, a heterocyclic group (the aryl group and the heterocyclic group may be substituted with 1 to 4 substituents which are the same or different and are selected from “a halogen atom, a hydroxy group, a cyano group, a nitro group, an amino group, a carboxy group and a C1-6 alkyl group”), a C1-6 alkylidene group (the C1-6 alkylidene group may be substituted with a C1-6 alkoxy group), a C3-8 cycloalkylidene group, a monocyclic saturated heterocyclidene group (the monocyclic saturated heterocyclidene group may be substituted with 1 to 2 C1-6 alkyl groups), and a hydroxyaminocarbonyl group. |
