Treatment regimen for N-MYC, c-MYC, and L-MYC amplified and overexpressed tumors

摘要

The present invention relates to methods and compositions for treating diseases. More specifically, the present invention relates to the administration of multiple drugs as part of a treatment of disease. Specific embodiments of the invention relate to a treatment regimen for neuroblastomas and other N-MYC, c-MYC, and L-MYC amplified and overexpressed tumors, comprising administering multiple therapeutic compounds like DFMO, SAM486A, a verinoid and a cytotoxic drug and placing the patient on a low polyamine diet and/or providing the patient with a polyamine limiting dietary supplement.

主权项

1. A method of treating N-MYC amplified and overexpressed tumors in a mammal, comprising: administering to said mammal a composition comprising therapeutically effective amounts of alpha-difluoromethylornithine (DFMO) and etoposide, wherein administration of the composition results in inhibition of abnormal cell proliferation, wherein the N-MYC amplified and overexpressed tumor is a neuroblastoma tumor.