| 主权项 |
1. A quaternary ammonium salt compound represented by general formula (I):wherein
R1 represents a hydrogen atom or an unsubstituted C1-8 alkyl group; R2 represents a single bond, unsubstituted C1-8 alkylene or C1-8 alkylene substituted on carbon atoms by 1 to 2 oxygen atoms, unsubstituted C2-4 alkenylene, or unsubstituted —O—C1-4 alkylene; X represents a single bond, —O—, —CONR3—, —NR3CO—, or —NR3CO—CH2—O—; where R3 represents a hydrogen atom or an unsubstituted C1-8 alkyl group; A1 represents a single bond, unsubstituted C6-10 arylene or C6-10 arylene substituted with 1 to 4 substituents selected from the group consisting of halogen atom, hydroxyl group, cyano group, nitro group, carboxyl group, trifluoromethyl group, unsubstituted C1-6 alkyl group, unsubstituted C3-8 cycloalkyl group, unsubstituted C1-6 alkoxy group, unsubstituted C3-8 cycloalkyloxy group, mercapto group, unsubstituted C1-6 alkylthio group, unsubstituted C3-8 cycloalkylthio group, amino group, unsubstituted mono(C1-6 alkyl)amino group and unsubstituted di(C1-6 alkyl)amino group, unsubstituted 5- to 10-membered heteroarylene or 5- to 10-membered heteroarylene substituted with 1 to 4 substituents selected from the group consisting of halogen atom, hydroxyl group, cyano group, nitro group, carboxyl group, trifluoromethyl group, unsubstituted C1-6 alkyl group, unsubstituted C3-8 cycloalkyl group, unsubstituted C1-6 alkoxy group, unsubstituted C3-8 cycloalkyloxy group, mercapto group, unsubstituted C1-6 alkylthio group, unsubstituted C3-8 cycloalkylthio group, amino group, unsubstituted mono(C1-6 alkyl)amino group and unsubstituted di(C1-6 alkyl)amino group, unsubstituted C1-4 alkylene-substituted or unsubstituted C6-10 arylene where the substituents of C6-10 arylene are 1 to 3 substituents selected from the group consisting of halogen atom, hydroxyl group, cyano group, nitro group, carboxyl group, trifluoromethyl group, unsubstituted C1-6 alkyl group, unsubstituted C3-8 cycloalkyl group, unsubstituted C1-6 alkoxy group, unsubstituted C3-8 cycloalkyloxy group, mercapto group, unsubstituted C1-6 alkylthio group, unsubstituted C3-8 cycloalkylthio group, amino group, unsubstituted mono(C1-6 alkyl)amino group and unsubstituted di(C1-6 alkyl)amino group, unsubstituted C1-4 alkylene-substituted or unsubstituted 5- to 10-membered heteroarylene where the substituents of 5- to 10-membered heteroarylene are 1 to 3 substituents selected from the group consisting of halogen atom, hydroxyl group, cyano group, nitro group, carboxyl group, trifluoromethyl group, unsubstituted C1-6 alkyl group, unsubstituted C3-8 cycloalkyl group, unsubstituted C1-6 alkoxy group, unsubstituted C3-8 cycloalkyloxy group, mercapto group, unsubstituted C1-6 alkylthio group, unsubstituted C3-8 cycloalkylthio group, amino group, unsubstituted mono(C1-6 alkyl)amino group and unsubstituted di(C1-6 alkyl)amino group, or unsubstituted C3-8 cycloalkylene or C3-8 cycloalkylene substituted with 1 to 3 substituents selected from the group consisting of halogen and unsubstituted C1-6 alkyl group; R4 represents unsubstituted C1-10 alkylene; R8 and R9 each independently represent a halogen atom, a cyano group, an unsubstituted C1-6 alkyl group, a nitro group, —NR10R11 where R10 and R11 each independently represent a hydrogen atom or an unsubstituted C1-6 alkyl group, an unsubstituted C1-6 alkoxy group, a carboxyl group, an unsubstituted C1-6 alkoxycarbonyl group, a hydroxyl group, a trifluoromethyl group, a mercapto group, or an unsubstituted C1-6 alkylthio group; a and b each independently represent an integer of 0 to 3; Y represents a group represented by formula (II): Q represents formula (III):wherein
R6 and R7 each independently represent an unsubstituted C1-6 alkyl group or a C1-6 alkyl group substituted with 1 to 4 substituents selected from the group consisting of halogen atom, hydroxyl group and unsubstituted C1-6 alkoxy group, or an unsubstituted C8-10 phenoxyalkyl group or a C8-10 phenoxyalkyl group substituted with 1 to 4 substituents selected from the group consisting of halogen atom, hydroxyl group, unsubstituted C1-6 alkyl group and unsubstituted C1-6 alkoxy group; R5 represents an unsubstituted C1-6 alkyl group or a C1-6 alkyl group substituted with 1 to 4 substituents selected from the group consisting of halogen atom, hydroxyl group and unsubstituted C1-6 alkoxy group; n represents an integer of 1; and m represents an integer of 0 to 3; W− represents a negative ion;or a pharmaceutically acceptable salt thereof. |
