Tumor antigen proteins or genes of polo-like kinase 1

摘要

The present invention relates to tumor antigen proteins or genes derived from polo-like kinase 1. As a result of the formation of a complex by binding polo-like kinase 1-derived proteins or variants having characteristics functionally identical to the proteins with MHC class I antigens or II antigens, the complex can be recognized by cytotoxic T lymphocytes. Therefore, the polo-like kinase 1-derived proteins or variants are identified as a tumor antigen which can be generally used in tumor immunotherapy.

主权项

1. An antigen-presenting cell which has a complex of MHC class I antigen or II antigen and a tumor antigen comprising a polo-like kinase 1-derived protein consisting of amino acid sequence of SEQ ID NO: 3, presented on the surface of cell having antigen-presentation capacity.