Pressure-regulating vial adaptors and methods

摘要

In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

主权项

1. A pressure-regulating vial adaptor configured to couple with a sealed vial, the adaptor comprising:
a housing portion comprising:
a piercing member comprising a regulator channel and an extractor channel;a regulator aperture in fluid communication with the regulator channel; anda medical device connection port in fluid communication with the extractor channel; a one-way valve in fluid communication with the regulator aperture, wherein the valve is configured to permit air to pass into the regulator channel but to prevent any air or fluid from passing through the valve from the regulator channel; and a rigid portion having a fixed volume and including a flexible member, the flexible member dividing the fixed volume of the rigid portion into a first portion and a second portion, the first portion being open to ambient pressure, the second portion being in fluid communication with the regulator aperture, the flexible member being configured to move in response to a pressure difference between the first portion and the second portion; wherein, when fluid is introduced into the vial via the extractor channel, the volume of the first portion decreases and the volume of the second portion increases.