Cardiomyocyte- and/or cardiac progenitor cell-proliferating agent and method for proliferating cardiomyocytes and/or cardiac progenitor cells

摘要

A method for proliferating cardiomyocytes and/or cardiac progenitor cells is disclosed. The proliferation method includes contact with at least one compound such as a GSK3β inhibitor, ERK dephosphorylation inhibitor, Raf activator, CaMK2 inhibitor and p38 inhibitor. The cardiomyocyte and the cardiac progenitor cell may be a human cardiomyocyte or human cardiac progenitor cell and may be obtained from differentiation of induced pluripotent stem cells.

主权项

1. A method for proliferating cardiomyocytes and/or cardiac progenitor cells, comprising contacting cultured cardiomyocytes and/or cardiac progenitor cells with GSK3β inhibitor, and p38 inhibitor, wherein the cardiomyocyte is a human cardiomyocyte and the cardiac progenitor cell is a human cardiac progenitor cell.