Transdermal dosage form for low-melting point active agent

摘要

A drug-containing patch allows transdermal administration of a drug. The patch features a hydrophobic reservoir containing the drug, where the reservoir has a first surface and a second surface. A drug-impermeable backing overlies the first surface of the reservoir. A release sheet may overlie the second surface of the reservoir. The hydrophobic reservoir contains a drug and a hydrophobic matrix, where the hydrophobic matrix includes a hydrophobic filler in an amount which is effective to adsorb said drug; and a mixture of polyisobutylene and mineral oil. The hydrophobic matrix may contain hydrophobic colloidal silica as the hydrophobic filler.;The hydrophobic reservoir layer may serve as a skin-contacting adhesive layer. Alternatively, a release-controlling adhesive layer may serve as the skin-contacting adhesive layer. The release-controlling adhesive layer may contain hydrophobic colloidal silica and a mixture of polyisobutylene and mineral oil.

主权项

1. A hydrophobic patch for transdermal administration of a hydrophobic drug, comprising:
a hydrophobic reservoir having a first surface and a second surface; a backing layer overlying said first surface, said backing being impermeable to said drug; and optionally a release sheet overlying said second surface; said hydrophobic reservoir comprising a hydrophobic matrix and said hydrophobic drug, said drug being homogeneously dispersed through said hydrophobic matrix, said hydrophobic matrix comprising:
from about 9% to about 30% by weight of said reservoir of hydrophobic colloidal silica dispersed through said hydrophobic matrix; and a mixture of mineral oil and polyisobutylene;
wherein said hydrophobic colloidal silica adsorbs at least a portion of said drug; andwherein a weight ratio of said mineral oil to said polyisobutylene is between about 0.087:1 and about 0.50:1.