Nano-particle surface modification

摘要

Oxide, oxysulfide, or phosphate host particles with a self-assembled organo-phosphonate monolayer covalently bonded thereto are disclosed. Methods for coating the host particles and use of rare earth ion-doped particles in imaging methods and photodynamic therapy methods are also disclosed.

主权项

1. Particles comprising oxide, oxysulfide, or phosphate host particles with a self-assembled monolayer consisting of organophosphonate ligands covalently bonded thereto, wherein said host particles comprise ions of one or more rare earth elements, wherein said covalent bonding to the host particle surfaces is via tridentate phosphonate coordination, wherein said particles are less than about 100 microns in size, and wherein said organophosphonate ligands are of formula:
R—P(═O)(—OH)2 wherein R is selected from the group consisting of linear alkyl, branched alkyl, linear alkylenyl, and branched alkylenyl moieties having from about two to about 40 carbon atoms, 0 to about 20 heteroatoms selected independently from oxygen and nitrogen, and omega-functionalized organic moieties, and wherein a photosensitizer compound or one or more biomolecular probes are covalently attached via said omega-functionalized organic moieties.