发明名称 |
Use of <i>PTEN</i>-long leader sequence for transmembrane delivery of molecules |
摘要 |
A composition for delivering cargo molecules across biological membranes is provided comprising (i) a peptide comprising consecutive amino acid residues having the sequence set forth in SEQ ID NO 1 for the transport of a cargo molecule across a biological membrane and (ii) the cargo molecule, wherein the cargo molecule is not a peptide comprising amino acid residues having the sequence set forth in SEQ ID NO 4. Methods of delivering cargo molecules across biological membranes are also provided. Methods of treating a tumor, cancer, a metabolic disorder, and a cardiovascular disorder are also provided. |
申请公布号 |
US9074011(B2) |
申请公布日期 |
2015.07.07 |
申请号 |
US201113579025 |
申请日期 |
2011.02.17 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
Parsons Ramon |
分类号 |
A61K38/00;C07K14/47;A61K47/48;C12N9/16 |
主分类号 |
A61K38/00 |
代理机构 |
Cooper & Dunham LLP |
代理人 |
White John P.;Cooper & Dunham LLP |
主权项 |
1. A composition comprising (i) a peptide comprising consecutive amino acid residues 22-173 of the sequence set forth in SEQ ID NO:1, or a portion of amino acid residues 22-173 of SEQ ID NO:1, for the transport of a cargo molecule across a biological membrane and (ii) the cargo molecule, wherein the cargo molecule is not a peptide comprising amino acid residues having the sequence set forth in SEQ ID NO:4, wherein the cargo molecule is attached to the peptide for transport via a polymeric linker. |
地址 |
New York NY US |