| 发明名称 | Anti-IL-17 receptor A neutralizing antibodies | ||
| 摘要 | The present invention relates to the identification of neutralizing determinants on IL-17 Receptor A (IL-17RA or IL-17R) and the antigen binding proteins, such as antibodies, that bind thereto and inhibit IL-17 ligand family members from binding to and activating IL-17 Receptor A or a receptor complex comprising IL-17 Receptor A. | ||
| 申请公布号 | US9073999(B2) | 申请公布日期 | 2015.07.07 |
| 申请号 | US201012785200 | 申请日期 | 2010.05.21 |
| 申请人 | KIRIN-AMGEN, INC. | 发明人 | Tocker Joel;Mehlin Christopher;Lim Ai Ching |
| 分类号 | C07K16/28;A61K39/395;A61K45/06;A61K39/00 | 主分类号 | C07K16/28 |
| 代理机构 | Marshall, Gerstein & Borun LLP | 代理人 | Marshall, Gerstein & Borun LLP |
| 主权项 | 1. An isolated antibody, comprising an anti-human IL-17 receptor A human monoclonal antibody, wherein said antibody has an EC50 value between 0.018 to 0.134 nM (inclusive) for a polypeptide consisting of SEQ ID NO: 431 and an EC50 value of 0 nM for a polypeptide consisting of SEQ ID NO: 436. | ||
| 地址 | Thousand Oaks CA US | ||