| 发明名称 | Targets for regulation of angiogenesis | ||
| 摘要 | The present invention relates to the identification of polynucleotides and polypeptides having increased expression in tumor blood vessels. The invention further relates to the use of the identified polynucleotides and polypeptides, and inhibitors of the polynucleotides and polypeptides, in the regulation of angiogenesis and the diagnosis and treatment of angiogenesis-related diseases such as cancer. | ||
| 申请公布号 | US9073982(B2) | 申请公布日期 | 2015.07.07 |
| 申请号 | US201414222926 | 申请日期 | 2014.03.24 |
| 申请人 | The University of North Carolina at Chapel Hill | 发明人 | DeMore Nancy Klauber;Patterson Cam;Bhati Rajendra;Bone Bradley G. |
| 分类号 | A61K39/395;C12P21/08;C07K16/00;A61K38/00;C07K16/18;A61K38/13;C07K16/28;C07K16/40;C12N15/113;G01N33/574 | 主分类号 | A61K39/395 |
| 代理机构 | Myers Bigel Sibley & Sajovec, P.A. | 代理人 | Myers Bigel Sibley & Sajovec, P.A. |
| 主权项 | 1. An isolated monoclonal antibody or an antigen binding fragment thereof which specifically binds an epitope comprised of amino acids selected from the group consisting of amino acids EITYINRDTKIILETKSKT-Cys (SEQ ID NO:6) and ITSVKRWQKGQREFKRISRSIRKLQC (SEQ ID NO:7). | ||
| 地址 | Chapel Hill NC US | ||