Antiviral compounds with a dibenzooxaheterocycle moiety

摘要

Disclosed are compounds of formula (I) for use as antiviral agents, particularly as anti-hepatitis virus C agents, wherein R-R 6 and q are as described herein. Also disclosed are pharmaceutical compositions and methods of treating or preventing viral infection in a host by the use of these compounds, either alone or in combination with other pharmaceutically active agents. Further disclosed are methods of preparing such compounds. (I).;

主权项

1. A compound of formula (I), a tautomeric form, a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein, R1 and R2 are each independently selected from hydrogen, substituted- or unsubstituted-alkyl, substituted- or unsubstituted-cycloalkyl, substituted- or unsubstituted-aryl, substituted- or unsubstituted-heteroaryl, substituted- or unsubstituted-heterocyclyl, R7aC(═O)—, R7aS(═O)2—, R7aOC(═O)—, (R8)R7NC(═O)—, R7aOC(═O)N(R8)CRb(Ra)C(═O)—, R7aOC(═O)N(R8)CRb(Ra)C(Rd)(Rc)C(═O)—, R7aC(═O)N(R8)C(Rb)(Ra)C(═O)—, R7aC(═O)N(R8)CRb(Ra)C(Rd)(Rc)C(═O)—, (R8)R7NC(═O)N(R9)C(Rb)(Ra)C(═O)—, and R8(R7)NC(═O)N(R9)CRb(Ra)C(Rd)(Rc)C(═O)—; R3 and R4 are each independently selected from hydrogen, halogen, substituted- or unsubstituted-alkyl, and substituted- or unsubstituted-cycloalkyl; R5 and R6 are independently selected form hydrogen and substituted- or unsubstituted-alkyl; or R5 and R6 are groups, which together with the carbon atom to which they are attached form a substituted- or unsubstituted-3 to 6 membered carbocycie or a substituted- or unsubstituted-5 to 6 membered heterocycle; or R5 and R6 are groups, wherein two R5 groups attached to two different carbon atoms, two R6 groups attached to two different carbon atoms, or an R5 group attached to one carbon atom and an R6 group attached to a different carbon atom, together with the carbon atoms to which they are attached form a substituted- or unsubstituted-3 to 6 membered carbocycle or a substituted- or unsubstituted-5 to 6 membered heterocycle; R7 is selected from hydrogen, substituted- or unsubstituted-alkyl, substituted- or unsubstituted-cycloalkyl, substituted- or unsubstituted-aryl, substituted- or unsubstituted-heteroary, and substituted- or unsubstituted-heterocyclyl; R8 and R9 are each independently selected from hydrogen and substituted- or unsubstituted-alkyl; R7a is independently selected from substituted- or unsubstituted-alkyl, substituted- or unsubstituted-cycloalkyl, substituted- or unsubstituted-aryl, substituted- or unsubstituted-heteroaryl, and substituted- or unsubstituted-heterocyclyl; Ra, Rb, Rc and Rd are independently selected from hydrogen, substituted- or unsubstituted-C1-6 alkyl, substituted- or unsubstituted-aryl, substituted- or unsubstituted-heteroaryl, substituted- or unsubstituted-cycloalkyl, and substituted- or unsubstituted-heterocyclyl, or Ra, Rb, Rc and Rd together with the carbon atom(s) to which they are attached forming substituted- or unsubstituted-carbocycle, substituted- or unsubstituted-heterocycle; p is an integer selected from 1, 2, and 3; when the alkyl group is a substituted alkyl group, the alkyl is substituted with 1 to 4 substituents selected independently from oxo, halogen, cyano, perhaloalkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, R10aO—, (alkyl)S(═O)2—, (alkyl)C(═O)—, (alkyl)OC(═O)—, (alkyl)C(═O)O—, R10N(H)C(═O)—, R10(alkyl)NC(═O)—, (alkyl)C(═O)N(H)—, R10N(H)—, R10(alkyl)N—, R10(H)NC(═O)N(H)—, and R10(alkyl)NC(═O)N(H)—; when the ‘cycloalkyl’ and the carbocyclic groups are substituted, each of them is substituted with 1 to 3 substituents selected independently from oxo, halogen, cyano, C1-6 alkyl, perhaloalkyl, R10aO—, (alkyl)S(═O)2—, (alkyl)C(═O)—, (alkyl)OC(═O)—, (alkyl)C(═O)O—, R10(H)NC(═O)—, R10(alkyl)NC(═O)—, (alkyl)C(═O)N(H)—, R10(H)N—, R10(alkyl)N—, R10(H)NC(═O)N(H)—, and R10(alkyl)NC(═O)N(H)—; when the aryl group is substituted, it is substituted with 1 to 3 substituents selected independently from halogen, cyano, hydroxy, C1-6 alkyl, perhaloalkyl, alkyl-O—, perhaloalkyl-O—, alkyl(alkyl)N—, alkyl(H)N—, H2N—, alkyl-S(═O)2—, alkyl-C(═O)(alkyl)N—, alkyl-C(═O)N(H)—, alkyl(alkyl)NC(═O)—, alkyl(H)NC(═O)—, H2NC(═O)—, alkyl(alkyl)NS(═O)2—, alkyl(H)NS(═O)2—, and H2NS(═O)2—; when the heteroaryl group is substituted, it is substituted with 1 to 3 substituents selected independently from halogen, cyano, hydroxy, C1-6 alkyl, perhaloalkyl, alkyl-O—, perhaloalkyl-O—, alkyl(alkyl)N—, alkyl(H)N—, H2N—, alkyl-S(═O)2—, alkyl-C(═O)(alkyl)N—, alkyl-C(═O)N(H)—, alkyl(alkyl)NC(═O)—, alkyl(H)NC(═O)—, H2NC(═O)—, alkyl(alkyl)NS(═O)2—, alkyl(H)NS(═O)2—, and H2NS(═O)2—; when the heterocyclic group is substituted, it can be substituted either on a ring carbon atom or a ring heteroatom; when it is substituted on a ring carbon atom, it is substituted with 1-3 substituents selected independently from halogen, cyano, oxo, C1-6 alkyl, perhaloalkyl, R10aO—, (alkyl)OC(═O)—, (alkyl)C(═O)O—, R10(H)NC(═O)—, R10(alkyl)NC(═O)—, (alkyl)C(═O)N(H)—, R10(H)N—, R10(alkyl)N—, R10(H)NC(═O)N(H)—, and R10(alkyl)NC(═O)N(H)—; when the ‘heterocyclic’ group is substituted on a ring heteroatom, it is substituted with 1 or more substituents selected from C1-6 alkyl, (alkyl)SO2—, (alkyl)C(═O)—, (alkyl)OC(═O)—, R10(H)NC(═O)—, and R10(alkyl)NC(═O)—; R10 is selected from hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl; and R10a is selected from hydrogen, alkyl, perhaloalkyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl.