| 主权项 |
1. A compound having structural Formula I: or a pharmaceutically acceptable salt thereof wherein: represents: R7 is selected from —H, —F, —CH3, —CF3, —CHF2, —CH2F, —CH2OH, cyclopropyl or —CH2C(═O)O—CH3, or R7 represents di-substitution on a single carbon with two of —F or two of —CH3; Z1 is selected from: Z2 is selected from: one of W1 and W2 is N and the other is CH; R1 and R2 are each independently selected from —H, —F, —Cl, —Br, —C3—C6cycloalkyl, —OR8, —SR8, —SOR8, —SO2R8, —(CH2)nOR8 or —C1-6alkyl optionally substituted with 1-3 of —F; one of R3a and R3b is selected from —CN, —NO2 or tetrazoly, and the other is R3c wherein R3c selected from —H, —F, —Cl, —Br, —CH3, —S—CH3, —NH—CH3, —O-cyclopropyl or —OC1-3alkyl optionally substituted with 1-3 of —F; one of R4a and R4b is selected from CN, —NO2 or tetrazolyl, and the other is R4c wherein R4c is selected from —H, —F, —Cl, —Br, —CH3, —S—CH3, —NH—CH3, —O-cyclopropyl or —OC1-3alkyl optionally substituted with 1-3 of —F; Ra, Raa, Rb and Rbb are each independently selected from —H, —F, —Cl, —CH3 optionally substituted with 1 to 3 of —F, or —OCH3 optionally substituted with 1 to 3 of —F; Rc and Rd are each independently selected from —H, —F, —Cl, —C1-6alkyl optionally substituted with 1 to 3 of —F, —C3-6cycloalkyl or —OC1-6alkyl optionally substituted with 1 to 3 of —F; Re and Rf are each independently selected from —H or —CH3; X and X1 are each independently selected from —H or —C1-6alkyl, or X1 is joined together with Z1 and the carbon to which both are attached to form a fused ring system selected from: Y and Y1 are each independently selected from —H or —C1-6alkyl, or Y1 is joined together with Z2 and the carbon to which both are attached to form a fused ring system selected from R5 and R6 are each independently selected from —H, —C1-6 alkyl or —C(O)OC1-3alkyl; and R8 is selected from —C1-6alkyl or —C3-6cycloalkyl. |
