| 摘要 |
The present invention relates to a method of making indeno-fused naphthol materials, that involves, with some embodiments, forming an indanone acid intermediate, represented by the following general Formula V,;
With Formula V, m is from 0 to 4, and R1 for each m, Rg and Rh can each be independently selected from, for example, hydrogen and hydrocarbyl. |
| 主权项 |
1. A method of making an indeno-fused naphthol represented by Formula I, wherein, m and n are each independently selected from 0 to 4, R1 for each m is halogen or R10′, wherein R10′ is hydrogen, R2 for each n is independently hydrocarbyl optionally interrupted with at least one of —O—, or —S—, and combinations thereof; substituted hydrocarby interrupted with at least one of —O—, or −S—, and combinations thereof; and halogen, and Rg and Rh are each independently hydrogen or Hydrocarbyl, said method comprising, (a) reacting an alkyl benzene represented by Formula II with maleic anhydride in the presence of a bishydrocarbyl peroxide represented b the formula Ra—O—O—Rb where Ra and Rb are each independently hydrocarbyl or substituted hydrocarbyl,
thereby forming a succinic acid substituted intermediate represented by Formula III, (b) converting the succinic acid substituted intermediate represented by Formula III to a succinic anhydride substituted intermediate represented by Formula IV, (c) converting the succinic anhydride substituted intermediate represented by Formula IV to an indanone acid intermediate represented by Formula V, (d) reacting the indanone acid intermediate represented by Formula V with a nucleophile represented by Formula VI to form a substituted indanone intermediate represented by at least one of Formula VIIa, Formula VIIb and Formula VIIc, wherein M represents a counterion comprising a metal selected from Mg, Li, Cu and combinations thereof, and (e) converting said substituted indanone intermediate represented by at least one of Formula VIIa, Formula VIIb and Formula VIIc to said indeno-fused naphthol represented by Formula I. |
