Methods and compositions for increasing the efficacy of an agent that directly or indirectly affects a muscarinic receptor through administration of a pyrophosphate analog

摘要

Methods and compositions for increasing the efficacy of an agent that directly or indirectly affects a muscarinic receptor by administering a pyrophosphate analog. Methods and compositions for protecting a pharmacological agent in a formulation, comprising combining the pharmacological agent with at least one pyrophosphate analog. Methods and compositions for increasing the efficacy of a neurologic agent by administering at least one pyrophosphate analog. Methods and compositions for increasing the efficacy of an agent that neither directly nor indirectly affects a muscarinic receptor by administering at least one pyrophosphate analog.

主权项

1. A method for increasing the efficacy of an agent that inhibits acetylcholinesterase in a subject suffering from Alzheimer's disease, comprising:
delivering an effective amount of pamidronate to a subject suffering from Alzheimer's disease that is concurrently receiving, has recently received, or will soon receive an agent that inhibits acetylcholinesterase; and increasing the efficacy of the agent that inhibits acetylcholinesterase in the subject in need thereof; wherein the effective amount of pamidronate is intranasally administered to the upper one third of the subject's nasal cavity, thereby enabling the pamidronate to bypass the subject's blood-brain barrier.