Method of improving cognitive functions in individuals with down syndrome and/or alzheimer's disease

摘要

A method of treating an individual having Down syndrome or Alzheimer's disease, which entails the step of administering an amount of one or more compounds to the individual which improve cognitive functioning in the individual by increasing hippocampal NE levels.

主权项

1. A method of improving contextual learning in a Down syndrome mammal, which comprises a step of:
administering from about 50 μg to about 800 μg/kg of body weight of a compound (A) selected from the group consisting of L-threo-DOPS, (+)-erythro-DOPS, and a racemic mixture of D- and L-threo-DOPS, and (B) one or more norepinephrine reuptake inhibitor compounds or pharmaceutically-acceptable salts of either compound A or the one or more norepinephrine reuptake inhibitor compounds (B) or both to the mammal in an amount and in a frequency of administration sufficient to improve the contextual learning, wherein the one or more norepinephrine reuptake inhibitor compounds are selected from the group consisting of atomoxetine, mazindol, nisoxetine, reboxetine, viloxazine, (R)-thionisoxetine and clomipramine.