| 发明名称 | Reverse genetics using non-endogenous pol I promoters | ||
| 摘要 | Expression of a transgene is driven in a host cell using a pol I promoter which is not endogenous to an organism from the same taxonomic order from which the host cell is derived. | ||
| 申请公布号 | US9072702(B2) | 申请公布日期 | 2015.07.07 |
| 申请号 | US201013320902 | 申请日期 | 2010.05.21 |
| 申请人 | Novartis AG | 发明人 | Dormitzer Philip;Franti Michael;Mason Peter;Suphaphiphat Pirada;Keiner Bjoern;Crotta Stefania |
| 分类号 | C12N7/02;C12N7/01;C12N5/10;C12N15/85;A61K39/12;A61K39/145 | 主分类号 | C12N7/02 |
| 代理机构 | Morrison & Foerster LLP | 代理人 | Morrison & Foerster LLP |
| 主权项 | 1. A method for producing a recombinant virus, comprising a step of growing a canine kidney host cell comprising at least one expression construct encoding a viral RNA molecule, wherein expression of the viral RNA molecule from the construct is controlled by a human pol I promoter under conditions where the viral RNA molecule is expressed in order to produce virus. | ||
| 地址 | Basel CH | ||