| 主权项 |
1. A compound of Formula I: or a stereoisomer, tautomer, pharmaceutical acceptable salt, or hydrate thereof, wherein:
W1 is selected from N and CR1;W2 is selected from N and CR2;W3 is selected from N and CR3;W4 is selected from N and CR4;each W may be the same or different from each other;A is selected from N and CH;R1, and R4 are each independently selected from hydrogen, alkyl, alkenyl, alkynyl, alkoxy, thioalkyl, aryloxy, aryl, amino, hydroxyl, and halogen;R2 and R3 are each independently selected from hydrogen, alkyl, alkenyl, alkynyl, alkoxy, thioalkyl, aryloxy, aryl, hydroxyl, and halogen; two adjacent substituents selected from R1, R2, R3, and R4 may be connected in a 5- or 6- membered ring to form a bicyclic carbocycle or bicyclic heterocycle; AR1 is a group selected from the following: B is a group selected from the following: each ring system may be substituted with one or more substituents independently selected from R10 and R11; R5 is selected from hydrogen, alkoxy, alkyl, thioalkyl, aryloxy, aryl, hydroxyl, and halogen; R6 is selected from hydrogen, alkoxy, alkyl, thioalkyl, aryloxy, aryl, and halogen; R7 is selected from hydrogen, alkyl, —SO2R12, —C(O)NR12R13, and —C(O)R12; R8 and R9 are independently selected from hydrogen, aryl, alkenyl, alkyl, —SO2R12, —C(O)NR12R13, and —C(O)R12; R10 and R11 are independently selected from hydrogen, halogen, alkyl, alkoxy, aryl, and hydroxyl; R12 and R13 are independently selected from hydrogen, aryl, and alkyl; Y is selected from NH, O, and S; and two adjacent substituents selected from R5, R6, R6, R9, R10, and R11 may be connected in a 5- or 6-membered ring to form a carbocycle or heterocycle. |
