tPA mutant in the treatment of acute brain injury and neurodegenerative disorders

摘要

The invention relates to tPA mutant devoid of protease activity and uses thereof in compositions and methods for the treatment and prevention of pathologic conditions involving neurological injury or an ischemic disease or condition. More specifically, the invention relates to a Ser481 to Ala mutant of tPA and to compositions and combinations thereof for the treatment of stroke, acute brain injury and neurodegenerative disorders. The invention further provides methods and kits for the treatment of said disorders.

主权项

1. A method for the treatment of acute or traumatic brain injury or cerebral ischemia, comprising administering to a subject suffering from said condition a therapeutically effective amount of a protein comprising a tPA mutated molecule devoid of serine protease activity, or a composition comprising the same, wherein said tPA mutated molecule has at least 522 amino acids that are identical to SEQ ID NO: 1 and has an alanine residue at the position corresponding to Ala483 of SEQ ID NO: 1.