发明名称 |
METHOD FOR CREATING NEW TAUOPATHY MODEL MOUSE |
摘要 |
<p>PROBLEM TO BE SOLVED: To create an animal model for reproducing a phenomenon in which the intracerebral distribution of a pathological structure containing tau spreads in a patient's brain of isolated tauopathy with time in a shorter period, and develop a method for screening the substance affecting the characteristics of the tau strand pathological structure in the isolated tauopathy brain using the animal model.SOLUTION: A method for creating an isolated tauopathy model mouse of the present invention includes a step of forming tau strands by incubation of a solution containing glycosaminoglycan connected with sulfate groups of four or more per a disaccharide sugar unit and a monomer of tau protein, and a step of injecting the tau strands into the brain of the mouse having only normal tau gene. The glycosaminoglycan has a case of a dextran sulfate or a polysulfate pentosan.</p> |
申请公布号 |
JP2015122979(A) |
申请公布日期 |
2015.07.06 |
申请号 |
JP20130268257 |
申请日期 |
2013.12.26 |
申请人 |
TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE |
发明人 |
SUZUKAKE MASAMI;HASEGAWA SHIGETO |
分类号 |
A01K67/027;G01N33/15;G01N33/50 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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