Beskyttet anti-neoplastisk middel omfattende en eller flere beskyttbare hydroksylgrupper, anvendelse derav samt sammensetning inneholdende midlet

摘要

The invention provides a protected anti-neoplastic agent of the formula Hyp-N, wherein N is an anti-neoplastic agent and a protectable hydroxyl group of the anti-neoplastic is substituted with Hyp; Hyp is a moiety having the formula:
wherein
R 2 is hydrogen;
R 3 is hydrogen or C 1 -C 6 alkyl;
R 1 is C 1 -C 6 alkyl or C 1 -C 6 alkoxy, optionally substituted with one or more heteroatom-containing groups; and
R 4 is hydrogen, C 1 -C 6 alkyl, or C 1 -C 6 alkoxy, optionally substituted with one or more heteroatom-containing groups.