The present invention relates to a process for the preparation of cefadroxil in crystal form, comprising:
a) adding an aqueous solution of cefadroxil to a crystallisation vessel and a titrant to keep a pH in the crystallisation vessel of between 7 to 9; and
b) lowering the pH in the crystallisation vessel to a value of between 5 and 6.5 to obtain a suspension of the ²-lactam compound in crystal form.
申请公布号
HK1199447(A1)
申请公布日期
2015.07.03
申请号
HK20140113022
申请日期
2014.12.29
申请人
DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.
发明人
LENHARDT, CARLOS ENRIQUE;MOODY, HAROLD, MONRO;DOOREN VAN, THEODORUS JOHANNES GODFRIED MARIA