| 摘要 |
The present application relates to novel 5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine derivatives of formula (I), as protein kinase inhibitors.;;The invention particularly relates to compounds of formula (I), preparation of compounds and pharmaceutical compositions thereof.;The invention further relates to prodrugs, derivatives, polymorphs, pharmaceutically acceptable salts and compositions comprising the said novel 5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine compounds and their derivatives and their use in the treatment of various disorders. |
| 主权项 |
1. A compound of formula (I);or pharmaceutically acceptable salts or stereoisomers thereof;wherein,
R1 and R2 are independently hydrogen, alkyl or haloalkyl; R3 and R4 are independently hydrogen, alkyl or cycloalkyl; each R5 is independently halogen, cyano, alkyl, —ORa, nitro, haloalkyl, —N(Rb)Rc, —C(O)ORa, —C(O)N(Rb)Rc, haloalkyloxy, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heterocyclyl; R6 is hydrogen, alkyl, —(CH2)nN(Rb)Rc, —(CH2)nOH or optionally substituted heterocyclyl; wherein the optional substituent is hydroxyalkyl; Ra is independently hydrogen, alkyl, cycloalkyl or haloalkyl; Rb and Rc are independently hydrogen, alkyl or —C(O)alkyl; ‘p’ is an integer 0 to 2 inclusive; ‘m’ is an integer 1 to 2 inclusive; ‘n’ is an integer 1 to 4 inclusive. |
