CROSS-LINKERS AND THEIR USES

摘要

PROBLEM TO BE SOLVED: To provide a novel cell-binding agent-drug conjugate having aqueous solubility.SOLUTION: The conjugate is represented by the formula (II). (CB represents a cell-binding agent; D represents a drug linked via a disulfide or the like; R1 to R10 are identical or different and are H, C1-6 linear alkyl, or a charged substituent such as SO3-, PO32- and trimethylammonium, or the like; l, m and n are integers between 0 and 4; A is non-existent or a polyoxyethylene group; Y is a carbonyl or the like; and q is an integer between 1 and 20.)