GENE EXPRESSION PROFILES TO PREDICT BREAST CANCER PROGNOSIS

摘要

PROBLEM TO BE SOLVED: To provide gene expression profiles to predict breast cancer prognosis.SOLUTION: Methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis of breast cancer intrinsic subtype. The prediction model is based on the gene expression profile of the intrinsic genes. This prediction model can be used to accurately predict the intrinsic subtype of a subject diagnosed with or suspected of having breast cancer. Further provided are compositions and methods for predicting prognosis or response to therapy of a subject diagnosed with or suspected of having breast cancer.