| 摘要 |
<p>PROBLEM TO BE SOLVED: To provide desferrithiocin polyether analogues and uses thereof.SOLUTION: Desferrithiocin analogues represented by the structural formulae described here, such as formula (I), are useful in treating conditions such as metal overload (e.g., iron overload from transfusion therapy), oxidative stress, and neoplastic and preneoplastic conditions. In another embodiment, the present invention is a method of treating a pathological condition responsive to chelation of a trivalent metal (e.g. Fe) in a subject, comprising administering to the subject a therapeutically or prophylactically effective amount of a compound, or a pharmaceutical composition thereof.</p> |
