主权项 |
1. A compound, or a pharmaceutically acceptable salt thereof, of Formula I wherein R1 is selected from the group consisting of H, lower alkyl and aryl; R2 and R3 together comprise a 4-6 member aliphatic, carbocyclic, or heterocyclic ring comprising 1 or 2 heteroatoms, each heteroatom selected from the group consisting of N, O and S; X is selected from the group consisting of CH2, NH, O, and S; ring A is a 6-membered aliphatic, aromatic, or heteroaromatic ring, wherein each R4 and R5 is independently selected from the group consisting of H, a first halogen, lower alkyl, —CF3, —OR8 and —SR9, with the proviso that R4 and R5 do not together comprise a ring; each of R8 and R9 is independently selected from the group consisting of H, lower alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, and arylaklyl; Z is selected from the group consisting of CH2, NH, O and S; and R6 is selected from the group consisting of H, amine, lower alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyloalkyl, aryl, arylalkyl, —OR12, —SR13, —NR14R15, —C(O)NR16R17, —NR18C(O)R19, —C(O)OR20, —NR21C(O)OR22, and —NR23C(O)NR24R25; wherein each of R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24 and R25 is independently selected from the group consisting of H, lower alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, and arylaklyl; and wherein lower alkyl is C1-C10 linear alkyl, C3-C10 branched alkyl, or C3-C10 cyclic alkyl and 0, 1, 2 or 3 carbons of a lower alkyl are replaced with a heteroatom, each heteroatom selected from the group consisting of N, O, and S. |