| 摘要 |
This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the invention are preferentially taken up by cancer cells as compared to normal cells. This allows many uses in the cancer treatment, diagnosis, tracking and imaging fields. |
| 主权项 |
1. A compound having formula:where X is selected from the group consisting of: hydrogen, halogen, CN, Me, phenyl, OH, OMe, OPh, 4-O-Ph-NH2, 4-O-Ph-CH2CH2COOH, 4-O-Ph-CH2CH2CONHS, NH-Ph, NHEt, SEt, S-Ph, 4-S-Ph-COOH, 4-S-Ph-OH, 4-O-Ph-COOH, 4-O-Ph-NCS, and 4-S-Ph-NCS; q is 0 or 1; R7 is selected from H and COOR9, where R9 is H, CH3, or CH2CH3; each R1 is independently in each instance, (CH2)mRA, where m is an integer from 1 to 12, RA is independently CH3, NH2, SH, COOH, SO3H, OH, halogen and CO—N-hydroxysuccinimide; each R10 is independently in each instance selected from H, OH, OMe, halogen, NH2, NHR, NR2 and COOH, where each R is independently C1-C6 alkyl; each R3 is independently in each instance, selected from the group consisting of: methyl and phenyl. |
