SULFONAMIDE-CONTAINING LINKAGE SYSTEMS FOR DRUG CONJUGATES
摘要
Sulfonamide-containing linkage systems for release of payload compounds from an attached targeting moiety in drug conjugates. The conjugates have the formula of [(P)-(L)]m-(T), wherein (P) is a payload compound, (L) is a linker, (T) is a targeting moiety and m is an integer from 1- to 10. Also provided are pharmaceutical compositions comprising such conjugates and there use in treating cancer.
申请公布号
WO2015095953(A1)
申请公布日期
2015.07.02
申请号
WO2014CA00920
申请日期
2014.12.29
申请人
THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT
发明人
WINTERS, GEOFFREY, C.;MANDEL, ALEXANDER, L.;BOURQUE, ELYSE, MARIE, JOSEE;RICH, JAMES, R.