| 发明名称 |
ALKYLATION OF AZOLES |
| 摘要 |
In one aspect, methods for the alkylation of azoles are described herein. In some embodiments, a method for the C2 alkylation of an azole compound comprises providing an azolium salt comprising an N-allyl substituent, reacting the N-allyl azolium salt with an aldehyde to provide a reaction product mixture comprising a ketone and N-allyl-N,X-ketene acetal, and providing the C2-alkylated azole compound by Claisen rearrangement of the N-allyl-N,X-ketene acetal, wherein X is selected from the group consisting of S, N and O. |
| 申请公布号 |
US2015183772(A1) |
申请公布日期 |
2015.07.02 |
| 申请号 |
US201314403727 |
申请日期 |
2013.05.24 |
| 申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS |
发明人 |
Mcintosh Matthias C.;Dormi Silvana;Rivero Juliette;Alwarsh Sefat;Ayinuola Kolawole |
| 分类号 |
C07D417/06;C07D277/64 |
主分类号 |
C07D417/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for C2 alkylation of an azole compound comprising:
providing an N-substituted azolium salt; reacting the N-substituted azolium salt with an aldehyde to provide a reaction product mixture comprising a ketone and an N-substituted-N,X-ketene acetal; and providing the C2-alkylated azole compound by rearrangement of the N-substituted-N,X-ketene acetal, wherein X is selected from the group consisting of S, N and O. |
| 地址 |
Little Rock AR US |
